The PIE-B (Preventing Infective Endocarditis-causing Bacteremia) trial is a multi-center, randomized clinical trial that will determine if an intervention to improve oral hygiene and reduce of gingival inflammation decreases the incidence and duration of bacteremia of infective endocarditis (IE)-causing oral bacterial species, which may refocus longstanding guidelines on prevention for all people at risk for IE.
Funder: National Institutes of Health, National Institute of Dental and Craniofacial Research.