An Enhanced Package of Care to Reduce Mortality in Persons with Advanced HIV Disease (ENCORE) is an ongoing community-based Phase III, cluster-randomized trial conducted in Uganda. The primary objective is to study whether enhanced screening and enhanced treatment for tuberculosis and cryptococcal infection will improve 6-month survival compared to current WHO-recommended standard practice in persons with advanced HIV disease.
Funder: National Institutes of Health, National Institute of Allergy and Infectious Diseases.