A Randomized Trial of Intra-portal Alone versus Intra- and Extra-portal Transplantation of Pancreatic Islets after Total Pancreatectomy for Chronic Pancreatitis (the iSite study) is a randomized pilot trial to assess the safety of receiving a portion of islets into an omental pouch during total pancreatectomy with islet auto-transplantation (TPIAT), compared to receiving all islets to the liver (intra-portal islet transplantation alone). The study will also examine quality of life, pain, and islet cell function, loss and engraftment.
Funder: U.S. Department of Defense.